Research Achievements

発表論文

• [New] Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice
  Eriya Kenjo, Hiroyuki Hozumi, Yukimasa Makita, Kumiko A. Iwabuchi, Naoko Fujimoto, Satoru Matsumoto, Maya Kimura, Yuichiro Amano, Masataka Ifuku, Youichi Naoe, Naoto Inukai & Akitsu Hotta

  Nature Communications volume 12, Article number: 7101 (2021)
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• A muscle fatigue-like contractile decline was recapitulated using skeletal myotubes from Duchenne muscular dystrophy patient-derived iPSCs
  Tomoya Uchimura, Toshifumi Asano, Takao Nakata, Akitsu Hotta, and Hidetoshi Sakurai

  Cell Rep Med. 2021 Jun 4;2(6):100298. doi: 10.1016/j.xcrm.2021.100298
  
  

• Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase
  Yukiko Yoshida,  Makoto Asahina, Arisa Murakami, Junko Kawawaki, Meari Yoshida,  Reiko Fujinawa,  Kazuhiro Iwai,  Ryuichi Tozawa,  Noriyuki Matsuda, Keiji Tanaka, and  Tadashi Suzuki

  PNAS July 6, 2021 118 (27) e2102902118; https://doi.org/10.1073/pnas.2102902118
  
  

• Reversibility of motor dysfunction in the rat model of NGLY1 deficiency
  Makoto Asahina, Reiko Fujinawa, Hiroto Hirayama, Ryuichi Tozawa, Yasushi Kajii and Tadashi Suzuki

  Molecular Brain 14, Article number :91, 2021
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• ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
  Kenji Miki, Kohei Deguchi, Misato Nakanishi-Koakutsu, Antonio Lucena-Cacace, Shigeru Kondo, Yuya Fujiwara, Takeshi Hatani, Masako Sasaki, Yuki Naka, Chikako Okubo, Megumi Narita, Ikue Takei, Stephanie C Napier, Tsukasa Sugo, Sachiko Imaichi, Taku Monjo, Tatsuya Ando, Norihisa Tamura, Kenichi Imahashi, Tomoyuki Nishimoto, and Yoshinori Yoshida

  Nature Communications 12, Article number :3596, 2021
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• A clinically applicable and scalable method to regenerate T-cell from iPSCs for off-the-shelf T-cell immunotherapy
  Shoichi Iriguchi, Yutaka Yasui, Yohei Kawai, Suguru Arima, Mihoko Kunitomo, Takayuki Sato, Tatsuki Ueda, Atsutaka Minagawa, Yuta Mishima, Nariaki Yanagawa, Yuji Baba, Yasuyuki Miyake, Kazuhide Nakayama, Maiko Takiguchi, Tokuyuki Shinohara, Tetsuya Nakatsura, Masaki Yasukawa, Yoshiaki Kassai, Akira Hayashi & Shin Kaneko
  Nature Communications 12, Article number:430, 2021
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• JF1/B6F1 Ngly1 -/- mouse as an animal model of NGLY1 deficiency
  Makoto Asahina
  Proceedings of the Japan Academy, Ser. B
  
  

• Current status and future perspectives of HLA-edited induced pluripotent stem cells
  Keiko Koga, Bo Wang & Shin Kaneko
  Inflammation and Regeneration 40, Article number:23, 2020
  
  

• The promise of human organoids in the digestive system
  Masaaki Funata, Yasunori Nio, Derek M. Erion, Wendy L. Thompson & Takanori Takebe
  Cell Death & Differentiation 28, 84-94 (2021)
  
  

• Prediction of Compound Bioactivities Using Heat-Diffusion Equation
  Tadashi Hidaka, Keiko Imamura, Takeshi Hioki, Terufumi Takagi, Yoshikazu Giga, Mi-Ho Giga, Yoshiteru Nishimura, Yoshinobu Kawahara, Satoru Hayashi, Takeshi Niki, Makoto Fushimi, Haruhisa Inoue
  Patterns Volume 1, Issue 9, 11 December 2020, 100140
  Details(JP)
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• Polygenic architecture informs potential vulnerability to drug-induced liver injury
  Masaru Koido, Eri Kawakami, Junko Fukumura, Yui Noguchi, Momoko Ohori, Yasunori Nio, Paola Nicoletti, Guruprasad P. Aithal, Ann K. Daly, Paul B. Watkins, Hisashi Anayama, Yvonne Dragan, Tadahiro Shinozawa & Takanori Takebe
  Nat Medicine (2020). https://doi.org/10.1038/s41591-020-1023-0
  (Detail)JP
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• Ngly1−/− rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems
  Makoto Asahina, Reiko Fujinawa, Sayuri Nakamura, Kotaro Yokoyama, Ryuichi Tozawa, Tadashi Suzuki
  Human Molecular Genetics, 2020 Apr https://doi.org/10.1093/hmg/ddaa059
  
  

• Peter Gee, Mandy S.Y. Lung, Yuya Okuzaki, Noriko Sasakawa, Takahiro Iguchi, Yukimasa Makita, Hiroyuki Hozumi, Yasutomo Miura, Lucy F. Yang, Mio Iwasaki, Xiou H. Wang, Matthew A. Waller, Nanako Shirai, Yasuko O. Abe, Yoko Fujita, Kei Watanabe, Akihiro Kagita, Kumiko A. Iwabuchi, Masahiko Yasuda, Huaigeng Xu, Takeshi Noda, Jun Komano, Hidetoshi Sakurai, Naoto Inukai, Akitsu Hotta
  Nature Communications, 11,2020
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• Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping
  
  

• Insulin-Deficient Diabetic Condition Upregulates the Insulin-Secreting Capacity of Human Induced Pluripotent Stem Cell–Derived Pancreatic Endocrine Progenitor Cells After Implantation in Mice
  Taisuke Mochida, Hikaru Ueno, Noriko Tsubooka-Yamazoe, Hideyuki Hiyoshi, Ryo Ito, Hirokazu Matsumoto, Taro Toyoda
  Diabetes 2020 Apr; 69(4): 634-646.
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• Identification of 2,6-Disubstituted-3Η-imidazo[4,5-b]pyridines as Therapeutic Agents for Dysferlinopathies through Phenotypic Screening on Patient-Derived iPSCs
  Hiroyuki Takada, Akira Kaieda, Michiko Tawada, Tomoko Nagino, Katsunori Sasa,
  Tatsuo Oikawa, Akiko Oki, Tomoya Sameshima, Kazumasa Miyamoto, Makoto Miyamoto, Yuko Kokubu, Ryuichi Tozawa, Hidetoshi Sakurai, Bunnai Saito
  Journal of Medicinal Chemistry, 2019 Oct 24;62(20):9175-9187

• Organoid Models of Development and Disease Towards Therapy
  Yasunori Nio, Takanori Takebe
  Medical Applications of iPS Cells, Springer Nature eBOOK, 2019, 149-168
  
  

• オルガノイド医療の可能性と課題
  Momoko Oohori, Yasunori Nio, Eri Kawakami
  実験医学 38(1): 44-49, 2020.
  
  

• Phenotypic Drug Screening for Dysferlinopathy Using Patient‐Derived Induced Pluripotent Stem Cells
  Yuko Kokubu, Tomoko Nagino, Katsunori Sasa, Tatsuo Oikawa, Katsuya Miyake, Akiko Kume, Mikiko Fukuda, Hiromitsu Fuse, Ryuichi Tozawa, Hidetoshi Sakurai
  Stem Cells Transl Med. 2019 Jun 28. doi: 10.1002/sctm.18-0280.
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• 肝オルガノイド技術を用いたiPS創薬戦略
  Eri Kawakami, Takanori Takebe
  細胞, 2019.04.01
  
  

• Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy
  Atsutaka Minagawa, Toshiaki Yoshikawa, Masaki Yasukawa, Akitsu Hotta, Mihoko Kunitomo, Shoichi Iriguchi, Maiko Takiguchi, Yoshiaki Kassai, Eri Imai, Yutaka Yasui, Yohei Kawai, Rong Zhang, Yasushi Uemura, Hiroyuki Miyoshi, Mahito Nakanishi, Akira Watanabe, Akira Hayashi, Kei Kawana, Shin Kaneko
  Cell Stem Cell, 2018, vol.23, 850-858
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