Research Achievements

（2020年3月現在）

Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy
Atsutaka Minagawa, Toshiaki Yoshikawa, Masaki Yasukawa, Akitsu Hotta, Mihoko Kunitomo, Shoichi Iriguchi, Maiko Takiguchi, Yoshiaki Kassai, Eri Imai, Yutaka Yasui, Yohei Kawai, Rong Zhang, Yasushi Uemura, Hiroyuki Miyoshi, Mahito Nakanishi, Akira Watanabe, Akira Hayashi, Kei Kawana, Shin Kaneko
Cell Stem Cell, 2018, vol.23, 850-858
（Detail）

Phenotypic Drug Screening for Dysferlinopathy Using Patient‐Derived Induced Pluripotent Stem Cells
Yuko Kokubu, Tomoko Nagino, Katsunori Sasa, Tatsuo Oikawa, Katsuya Miyake, Akiko Kume, Mikiko Fukuda, Hiromitsu Fuse, Ryuichi Tozawa, Hidetoshi Sakurai
Stem Cells Transl Med. 2019 Jun 28. doi: 10.1002/sctm.18-0280.
(Detail)

オルガノイド医療の可能性と課題
Momoko Oohori, Yasunori Nio, Eri Kawakami
実験医学 38(1): 44-49, 2020.

Organoid Models of Development and Disease Towards Therapy
Yasunori Nio, Takanori Takebe
Medical Applications of iPS Cells, Springer Nature eBOOK, 2019, 149-168

Identification of 2,6-Disubstituted-3Η-imidazo[4,5-b]pyridines as Therapeutic Agents for Dysferlinopathies through Phenotypic Screening on Patient-Derived iPSCs
Hiroyuki Takada, Akira Kaieda, Michiko Tawada, Tomoko Nagino, Katsunori Sasa,
Tatsuo Oikawa, Akiko Oki, Tomoya Sameshima, Kazumasa Miyamoto, Makoto Miyamoto, Yuko Kokubu, Ryuichi Tozawa, Hidetoshi Sakurai, Bunnai Saito
Journal of Medicinal Chemistry, 2019 Oct 24;62(20):9175-9187

Insulin-Deficient Diabetic Condition Upregulates the Insulin-Secreting Capacity of Human Induced Pluripotent Stem Cell–Derived Pancreatic Endocrine Progenitor Cells After Implantation in Mice
Taisuke Mochida, Hikaru Ueno, Noriko Tsubooka-Yamazoe, Hideyuki Hiyoshi, Ryo Ito, Hirokazu Matsumoto, Taro Toyoda
Diabetes 2020 Apr; 69(4): 634-646.
（Detail）

Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping
Peter Gee, Mandy S.Y. Lung, Yuya Okuzaki, Noriko Sasakawa, Takahiro Iguchi, Yukimasa Makita, Hiroyuki Hozumi, Yasutomo Miura, Lucy F. Yang, Mio Iwasaki, Xiou H. Wang, Matthew A. Waller, Nanako Shirai, Yasuko O. Abe, Yoko Fujita, Kei Watanabe, Akihiro Kagita, Kumiko A. Iwabuchi, Masahiko Yasuda, Huaigeng Xu, Takeshi Noda, Jun Komano, Hidetoshi Sakurai, Naoto Inukai, Akitsu Hotta
Nature Communications, 11,2020
（Detail）

Ngly1−/− rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems
Makoto Asahina, Reiko Fujinawa, Sayuri Nakamura, Kotaro Yokoyama, Ryuichi Tozawa, Tadashi Suzuki
Human Molecular Genetics, 2020 Apr https://doi.org/10.1093/hmg/ddaa059