Administrative procedures for shares

For American Depositary Shares (ADS) Holders

ADS Depositary Bank: The Bank of New York Mellon

ADS Holders can contact The Bank of New York Mellon via telephone, in writing or email as follows:

Telephone:
Toll Free Number within the United States: 1-888-BNY-ADRS (1-888-269-2377)
Number for International Calls: +1-201-680-6825

In writing:
The Bank of New York Mellon Depositary Receipts Division
240 Greenwich Street
New York, NY 10286, U.S.A.

Email: shrrelations@bnymellon.com

Website: http://www.adrbnymellon.com/



For Former Shire Shareholders (Ordinary Shares) who have not made an election in respect of the consideration

Please contact Corporate Nominee Facility, EQUINITI, via telephone or in writing as follows:

Telephone (Shareholder Helpline):
0330-123-5506 (+44-121-415-0856 if calling from outside the UK)
A text phone is also available on:
0371-384-2255 (+44-121-415-7028 if calling from outside the UK)
Lines open 8.30am to 5.30pm (UK time), Monday to Friday (excluding public holidays in England and Wales).

In writing:
The Manager, Equiniti Corporate Nominees Limited,
Aspect House, Spencer Road,
Lancing, West Sussex, BN99 6DA United Kingdom
Or you can send us your query securely by completing the online form at:
help.shareview.co.uk

In accordance with the Scheme of Arrangement Corporate Nominee Facility will end two (2) years from the Scheme Effective Date (January 8, 2019). After such time, any remaining shares will be sold and a Sterling cheque issued.
For further details, please see https://www.takeda.com/siteassets/system/investors/offer-for-shire-plc/november-12-2018---shire-scheme-document.pdf