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Directorate change

April 28, 2016

April 28, 2016 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) announces that Olivier Bohuon, Non-Executive Director of the Company, has been appointed as a member of the Remuneration Committee with immediate effect.

Oliver Strawbridge
Senior Assistant Company Secretary

For further information please contact:

Investor Relations    
Sarah Elton-Farr seltonfarr@shire.com +44 1256 894157

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.

We focus on providing treatments in Rare Diseases, Neuroscience, Gastrointestinal and Internal Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas, such as Ophthalmics.

www.shire.com