Shire to Present at the Cowen 35th Annual Healthcare Conference

February 25, 2015

Shire plc (LSE: SHP, NASDAQ: SHPG) today announced that Flemming Ornskov, MD, Chief Executive Officer, will present at the Cowen 35th Annual Healthcare Conference in Boston, MA on Tuesday, March 3, 2015 at 9:20 a.m. ET (2:20 p.m. GMT).

A live audio webcast will be available on the Presentations and Webcasts section of Shire's Investor website at http://www.shire.com/shireplc/en/investors/presentationswebcasts.

Subsequently, a replay of the webcast will be available on this same website for approximately 90 days.

For further information please contact:

Investor Relations

Sarah Elton-Farr
seltonfarr@shire.com
+44 1256 894157

Media

Stephanie Fagan
sfagan@shire.com
+1 201 572 9581

Jessica Cotrone
jcotrone@shire.com
+1 781 482 9538

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.

We focus on providing treatments in Rare Diseases, Neuroscience, Gastrointestinal and Internal Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas, such as Ophthalmics.

www.shire.com

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