Director Declaration

March 4, 2015

Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) announces that its Non-Executive Director, David Kappler, was appointed as a Non-Executive Director of Flybe Group plc with effect from March 3, 2015.

This notification is to satisfy the Company’s obligations under 9.6.14R of the UK Listing Rules.

Tony Guthrie
Deputy Company Secretary

For further information please contact:

Investor Relations

Sarah Elton-Farr
seltonfarr@shire.com
+44 1256 894157

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.

We focus on providing treatments in Rare Diseases, Neuroscience, Gastrointestinal and Internal Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas, such as Ophthalmics.

www.shire.com

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