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Director/PDMR Share Dealings

October 27, 2014

Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) announces it was notified today that Susan Kilsby, Chairman of the Company, acquired 2,500 American Depositary Shares (“ADSs”) on October 24, 2014 at an average price of US$194.4264 per ADS.  

Following the above transaction, Ms Kilsby holds 3,041 ADSs. One ADS is equal to three ordinary shares of 5 pence each in the Company.

This notification is to satisfy the Company’s obligations under 3.1.4(R)(1)(a) of the Disclosure and Transparency Rules.

Tony Guthrie
Deputy Company Secretary

For further information please contact:

Investor Relations  
Jeff Poulton 
jpoulton@shire.com
+1 781 482 0945

Sarah Elton-Farr 
seltonfarr@shire.com
+44 1256 894157

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.

We focus on providing treatments in Neuroscience, Rare Diseases, Gastrointestinal, and Internal Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas, such as Ophthalmology.

www.shire.com

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