Director/PDMR Share Dealings

Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) announces that today the following Persons Discharging Managerial Responsibility (“PDMRs”) acquired American Depositary Shares (“ADSs”) in the Company under the Shire Employee Stock Purchase Plan:

One ADS is equal to three Ordinary Shares of 5 pence each.

This notification is to satisfy the Company’s obligations under 3.1.4(R)(1)(a) of the Disclosure and Transparency Rules.

Tony Guthrie
Deputy Company Secretary

For further information please contact:

Investor Relations
Jeff Poulton
[email protected]
+1 781 482 0945

Sarah Elton-Farr
[email protected]
+44 1256 894157

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.

We focus on providing treatments in Neuroscience, Rare Diseases, Gastrointestinal, and Internal Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas, such as Ophthalmology.

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