Information About General Reserve and Other Voluntary Reserves

September 24, 2025

OSAKA, Japan and CAMBRIDGE, Massachusetts, September 25, 2025 – Takeda (TSE:4502/NYSE:TAK) announces that its Board of Directors approved, on September 24, 2025 (U.S. Eastern Time), a reversal of general reserve and unrestricted reversal of other voluntary reserves, as detailed below.

Takeda has established a provision in its Articles of Incorporation to the effect that the matters specified in each item of Paragraph 1, Article 459 of the Companies Act of Japan may be conducted by resolution of the Board of Directors.

This treatment within the net assets section on Takeda Pharmaceutical Company Limited’s balance sheet (unconsolidated) does not affect the consolidated financial results.

Details

Reversal of voluntary reserves listed below including the general reserve, and reclassification of those reserves to unappropriated retained earnings.

(1) Surplus items to be decreased, and their amounts (JPY)

Reserve for retirement benefits 5,000 million
Reserve for dividends 11,000 million
Reserve for research and development 2,400 million
Reserve for capital improvements 1,054 million
Reserve for promotion of exports 434 million
General reserve 814,500 million

(2) Surplus item to be increased, and the amount (JPY)

Unappropriated retained earnings 834,388 million

Reason for reversal of the general reserve and other voluntary reserves

To enable a flexible capital policy by effectively utilizing a portion of the internal reserves that were accumulated in the past and remained unused over many years.

Effective date

September 24, 2025

Impact on Consolidated Financial Results

There is no impact on consolidated financial results as this is a reclassification of accounts in the section of net assets of the balance sheet of Takeda Pharmaceutical Company Limited (unconsolidated) and there is no change in the amount of total net assets.

About Takeda Pharmaceutical Company Limited

Takeda is focused on creating better health for people and a brighter future for the world. We aim to discover and deliver life-transforming treatments in our core therapeutic and business areas, including gastrointestinal and inflammation, rare diseases, plasma-derived therapies, oncology, neuroscience and vaccines. Together with our partners, we aim to improve the patient experience and advance a new frontier of treatment options through our dynamic and diverse pipeline. As a leading values-based, R&D-driven biopharmaceutical company headquartered in Japan, we are guided by our commitment to patients, our people and the planet. Our employees in approximately 80 countries and regions are driven by our purpose and are grounded in the values that have defined us for more than two centuries. For more information, visit www.takeda.com.

Contacts

Investor Relations

Christopher O’Reilly

[email protected]

+81 (0) 3-3278-2543

Media Relations

Brendan Jennings

[email protected]

+81 (0) 80-2705-8259

(Outside Japan business hours)

[email protected]

Important Notice

For the purposes of this notice, “press release” means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this press release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.

The companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.

Forward-Looking Statements

This press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could”, “anticipates”, “estimates”, “projects” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations, including global health care reforms; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda’s operations and the timing of any such divestment(s); the extent to which our internal energy conservation measures and future advancements in renewable energy or low carbon energy technology will enable us to reduce our greenhouse gas emissions; and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: https://www.takeda.com/investors/sec-filings/ or at www.sec.gov. Takeda does not undertake to update any of the forward-looking statements contained in this report or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this report may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results.

**OSAKA, Japan and CAMBRIDGE, Massachusetts, September 25, 2025** – Takeda ([TSE:4502/NYSE:TAK](/investors/)) announces that its Board of Directors approved, on September 24, 2025 (U.S. Eastern Time), a reversal of general reserve and unrestricted reversal of other voluntary reserves, as detailed below. Takeda has established a provision in its Articles of Incorporation to the effect that the matters specified in each item of Paragraph 1, Article 459 of the Companies Act of Japan may be conducted by resolution of the Board of Directors. This treatment within the net assets section on Takeda Pharmaceutical Company Limited’s balance sheet (unconsolidated) does not affect the consolidated financial results. 1. Details Reversal of voluntary reserves listed below including the general reserve, and reclassification of those reserves to unappropriated retained earnings. (1) Surplus items to be decreased, and their amounts (JPY) * Reserve for retirement benefits 5,000 million * Reserve for dividends 11,000 million * Reserve for research and development 2,400 million * Reserve for capital improvements 1,054 million * Reserve for promotion of exports 434 million * General reserve 814,500 million (2) Surplus item to be increased, and the amount (JPY) * Unappropriated retained earnings 834,388 million 2. Reason for reversal of the general reserve and other voluntary reserves To enable a flexible capital policy by effectively utilizing a portion of the internal reserves that were accumulated in the past and remained unused over many years. 3. Effective date September 24, 2025 4. Impact on Consolidated Financial Results There is no impact on consolidated financial results as this is a reclassification of accounts in the section of net assets of the balance sheet of Takeda Pharmaceutical Company Limited (unconsolidated) and there is no change in the amount of total net assets. ## About Takeda Pharmaceutical Company Limited Takeda is focused on creating better health for people and a brighter future for the world. We aim to discover and deliver life-transforming treatments in our core therapeutic and business areas, including gastrointestinal and inflammation, rare diseases, plasma-derived therapies, oncology, neuroscience and vaccines. Together with our partners, we aim to improve the patient experience and advance a new frontier of treatment options through our dynamic and diverse pipeline. As a leading values-based, R&D-driven biopharmaceutical company headquartered in Japan, we are guided by our commitment to patients, our people and the planet. Our employees in approximately 80 countries and regions are driven by our purpose and are grounded in the values that have defined us for more than two centuries. For more information, visit [www.takeda.com](/). ## Contacts ### Investor Relations Christopher O’Reilly [[email protected]](mailto:[email protected]) +81 (0) 3-3278-2543 ### Media Relations Brendan Jennings [[email protected]](mailto:[email protected]) +81 (0) 80-2705-8259 (Outside Japan business hours) [[email protected]](mailto:[email protected]) ## Important Notice For the purposes of this notice, “press release” means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this press release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws. The companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies. ## Forward-Looking Statements This press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could”, “anticipates”, “estimates”, “projects” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations, including global health care reforms; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda’s operations and the timing of any such divestment(s); the extent to which our internal energy conservation measures and future advancements in renewable energy or low carbon energy technology will enable us to reduce our greenhouse gas emissions; and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: [https://www.takeda.com/investors/sec-filings/](https://www.takeda.com/investors/sec-filings) or at [www.sec.gov](https://www.sec.gov/). Takeda does not undertake to update any of the forward-looking statements contained in this report or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this report may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results.

Information About General Reserve and Other Voluntary Reserves | Takeda Pharmaceuticals