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Rare Diseases: Immunology

When it comes to rare and immune-mediated conditions, we serve individuals with these diseases and the physicians who treat them by providing therapies and services that can be tailored to each person’s unique needs - even as these needs change across the patient journey.

While each disease is different, the expectations of the individuals who live with them are similar. Takeda’s strength in immunology is built on deep expertise in delivering complex therapies for a variety of conditions.

We aim to provide intelligent, adaptable treatments that help manage and prevent serious conditions, supported by services that assist these individuals in finding the best therapy for their individual case, and adjusting the approach as their needs change. For patients with hereditary angioedema (HAE), we supply the freedom for them to live their lives, aided by patient services and next-generation therapies that improve their treatment experience.

We support patients with immune-mediated conditions including:

Hereditary angioedema (HAE)

Hereditary angioedema (HAE) is a rare disease that causes unexpected edema (swelling) in various parts of the body including extremities, the gastrointestinal tract, and upper airways. Depending on the severity of the disease, some people may have multiple attacks each month, while others will go several months without an attack.

Primary immunodeficiency (PI)

Primary immunodeficiency (PI) is a group of nearly 300 rare diseases concerning a part of the immune system that is missing or not functioning properly.2,3 People with PI may be more susceptible to illness, take longer to recover and have recurring infections4 such as sinusitis, bronchitis, pneumonia, or gastrointestinal infections.5 Physicians sometimes treat the infections while missing the underlying cause, leaving patients vulnerable to vital organ damage, physical disability, or even increased mortality risk.6,7


Blaese RM, Bonilla FA, Stiehm ER, Younger ME, eds. Patient & Family Handbook for Primary Immunodeficiency Diseases. 5th ed. Towson, MD: Immune Deficiency Foundation; 2013.

Bousfiha A, Jeddane I, Al-Herz W, et al. The 2015 IUIS phenotypic classification for primary immunodeficiencies. J Clin Immunol. 2015; 35(8): 727-738.

Immune Deficiency Foundation, “About Primary Immunodeficiencies: http://primaryimmune.org/about-primary-immunodeficiencies/. Accessed April 18, 2016.

Immune Deficiency Foundation, “About Primary Immunodeficiencies: Infections.” http://primaryimmune.org/about-primary-immunodeficiencies/relevant-info/infections/. Accessed April 18, 2016.

Riedl M, Rumbak M. Clin Pulm Med. 2010;17(2):88-95

Resnick ES, et al. Blood. 2012;119(7):1650-1657.