Notice Regarding the Determination of Subscription Requirements to Issue New Takeda Shares

January 6, 2019

Osaka, Japan, January 7, 2019 - Under the authority delegated by the resolution at the extraordinary shareholders meeting held on December 5, 2018, Takeda Pharmaceutical Company Limited (TSE: 4502/NYSE: TAK) (“Takeda”) has on January 5, 2019 determined the subscription requirements to issue new Takeda shares as a part of the consideration relating to the proposed acquisition of Shire plc (“Shire”) by Takeda as follows.

Type of shares for subscription

Ordinary shares of Takeda

Number of shares for subscription

770,303,013 shares

Amount per share to be paid in

JPY 7,601

Property other than monies to be contributed

Ordinary shares of Shire plc will be contributed.

Description of contributed property

918,120,398 ordinary shares of Shire plc.

Value of contributed property

JPY 5,855,073,208,821.12

Amounts of capital and capital reserves to be increased

The amount of stated capital to be increased shall be half of the maximum amount of increase in stated capital, as calculated in accordance with the provisions of Article 14, paragraph 1 of the Rules of Corporate Accounting, with any fraction less than one yen resulting from the calculation being rounded up to the nearest one yen. The amount of capital reserves to be increased shall be the amount obtained by subtracting the said amount of stated capital to be increased from the maximum amount of increase of stated capital.

Date of contribution

January 8, 2019