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Combination Treatments – Our proposal


At Takeda, we are guided by an unwavering commitment to put the patient first in everything we do. As part of this, we have a long history of collaborating with healthcare systems, regulatory bodies, health technology assessment bodies, payers and the clinical and patient communities to find solutions to complex challenges that enhance patient access to innovative treatments.

Combination treatments are becoming increasingly common as the understanding of complex diseases increases; particularly in areas such as cancer, HIV, rheumatoid arthritis and Hepatitis C. This is because using multiple treatments in combination can simultaneously target numerous pathways that drive a disease. However, despite potentially offering significant clinical benefits to patients, the availability of combination treatments remains a significant challenge as they often face cost-effectiveness barriers even when one of the treatments is given away at zero price.

There is consensus within key stakeholder groups, nationally and internationally, that solutions for accessing combination treatments need to be quickly found for the benefit of patient outcomes, now and in the future.

In partnership with experts from academia, clinical and patient communities, and with advice from experts from NICE & the NHS, Takeda has developed two Whitepapers setting out a proposed solution for improving access to combination treatments; the Value Attribution Framework and the Voluntary Arbitration Framework.

The Whitepapers can be accessed via the links below. An Attribution of Value Framework describes an economic methodology to attribute value to each treatment within a combination. The Voluntary Arbitration Framework, proposes a standard operating procedure to support compliant dialogue between pharmaceutical companies on combination treatments.

The proposed solution aims to contribute to the options being explored by other stakeholders to find transactable and implementable solutions that align with current NICE appraisal and NHS England commercial methods. We are passionate about working in partnership to find a solution that ensures patients can benefit from the potential of combination treatments as quickly as possible.

We welcome feedback, critique, and debate, of this solution so that we are able represent perspectives from all stakeholders.

Additional resources to provide further insight and opinion on the combination treatment landscape can be found below.

Please contact the team via: [email protected]





The combination treatment challenge brought to life in animation:


Takeda’s proposed solution brought to life in animation:



Takeda is a proud partner of the This is Blood Cancer Programme, spearheaded by Blood Cancer UK and ITN Productions, which explores the work being done to provide clinical trials, improve treatments and raise awareness of blood cancer in the UK. Takeda’s contribution to this programme brings to life the combination treatment access challenge, often faced by blood cancer medicines, and Takeda’s proposed solution. You can watch the film below, which is anchored by ITN Productions presenter Simon Thomas.



Date of Preparation: March 2024