Director Declaration

Shire plc (LSE: SHP, NASDAQ: SHPG) announces that, in accordance with Listing Rule LR 9.6.14, its non-executive director, Anne Minto, has been appointed as a Non-Executive Director to the Board of Directors of Tate & Lyle PLC, with effect from December 1, 2012.

Tony Guthrie
Deputy Company Secretary

For further information please contact:

Investor Relations      

Eric Rojas   
[email protected]
+1 781 482 0999

Sarah Elton-Farr   
[email protected]
+44 1256 894157

Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients’ needs, we develop and provide healthcare in the areas of:

• Behavioral Health and Gastro Intestinal conditions
• Rare Diseases
• Regenerative Medicine

as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for patients, physicians, policymakers, payors and our shareholders.