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Total Voting Rights

February 1, 2010

Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, in accordance with DTR 5.6.1 of the FSA’s Disclosure and Transparency Rules, notifies the market of the following:

At close of business on January 29, 2010, Shire plc's issued voting share capital consisted of 561,509,130 ordinary shares with a nominal value of 5 pence. Each ordinary share carries one voting right. Shire plc does not hold any shares in Treasury.

The above figure (561,509,130) may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, Shire plc under the FSA's Disclosure and Transparency Rules.

Tony Guthrie
Deputy Company Secretary