Platform technology (new modalities and drug delivery systems)

#25

Chemistry-driven novel methods or ideas to bring breakthrough into CNS drug discovery

We recruit a small molecule-based approach to a CNS therapeutic target. The followings are examples:

• Drug discovery research based on innovative mechanism of action
  (e.g.) Ligands acting on DNA/RNAs (incl. splicing modulators), Small molecule chemical chaperones

• Drug discovery research on tough targets
  (e.g.) Biased- or heterodimer-selective GPCR ligands, Allosteric ligands, Phosphatase inhibitors, Protein-protein interaction modulators

Note: Protein degradation inducer is recruited by subject #28.

#26

Chemistry-driven novel technologies, methods or ideas to solve issues on drug discovery with new modalities

We recruit research themes to solve issues in drug discovery using new modalities. The followings are examples:

• Investigation of technologies for the improvement of efficacy, selectivity, and biodistribution of antisense oligonucleotides and siRNA
• Research on Structure-Activity/Toxicity-Relationship in oligonucleotide drug discovery based on 3D structural analysis
• Research on brain-targeted drug delivery technologies and evaluation of their mechanisms of action
• Research on therapeutic modalities such as regenerative medicine and cell therapy using synthetic compounds
  
  

#27

Chemistry-driven novel technologies, methods or ideas to improve and/or accelerate drug discovery process

We recruit research themes to improve and/or accelerate the drug discovery process. The followings are examples:

• Development of novel drug discovery algorithms based on artificial intelligence and/or molecular simulation
  (e.g.) Pharmacological activity and/or adverse effect prediction. Design of novel compounds

• Drug discovery research based on polypharmacology
  (e.g.) Research on combination of therapeutic targets in terms of chemistry and pharmacology, Effective methodology for compound optimization

• Technology of system which accelerate phenotypic drug discovery
  (e.g.) annotation/drug repositioning libraries, novel synthesis/building blocks of photoaffinity labeling probes

• Development of in vitro/in vivo imaging probes for disease diagnosis, patient stratification
  
  

#28

Research on novel technologies and ideas in targeted protein degradation for drug discovery

We recruit research themes in targeted protein degradation area.

Areas of interest:

• Computational chemistry technology to accelerate drug discovery process for targeted protein degrader
• Drug discovery research on protein degradation inducer oriented to CNS therapeutic drug
• Discovery of chimera molecule for ubiquitination independent target protein degradation
• Research on teratogenicity of Cereblon (mechanism, evaluation method of teratogenicity, compound design in order to reduce the teratogenicity risk, etc.)
  
  

#29

Novel analysis methods and ideas associated with drug discovery based on human genetics

We recruit research themes that can accelerate drug discovery process by novel technology and idea based on human genetics.

Areas of interest:

• Novel analytical methods based on human genetics not limited to additive genetic model
• Prediction methods for the impact against genes or pathways by genomic variation (insertions, deletions, repeats, etc.)
• Exploratory research on master transcription factors related to diseases pathogenesis
• Structural biology research on epigenetics related to disease pathogenesis
  
  

#30

Novel analysis methods and ideas for exploring prediction-markers of disease-subpopulation based on human big data

We recruit research themes that can accelerate exploration of prediction-markers of disease-subpopulation based on human big data.

Areas of interest:

• Time series data generated by digital device (sleep, perspiration, acceleration, brain imaging, EEG, etc.)
• Omics data (Spatial transcriptome, Single cell, Exosome, etc.)
  
  

#31

Research on novel technologies and ideas of drug discovery targeting nucleic acids

We recruit research themes that can accelerate drug discovery process targeting nucleic acids.

Areas of interest:

• Computational chemistry technology to accelerate RNA-targeting drug discovery
• Research on synthetic compounds as innovative therapeutic modalities targeting nucleic acids
• Technology to extract biologically significant RNA sequences that a small molecule can target
  
  

#32

Development of efficient drug delivery technologies to skeletal and cardiac muscles

Although various drug delivery technologies have been developed recently, it is still difficult to efficiently deliver drugs to skeletal and/or cardiac muscles. Therefore, we are seeking ideas for delivery technologies that can deliver DNA, RNA, protein and chemical compound to skeletal and/or cardiac muscles efficiently.

Specific examples:

• Development of technologies to avoid or reduce the first-pass effect of liver
• Development of viral vectors capable of escaping from the neutralizing antibodies
• Development of delivery technologies by combining with other engineering technologies (ex, optical, magnetic, thermal or ultrasonic)
• Development of liposomes or exosomes with skeletal and/or cardiac muscle tropisms
• Regardless of above, technologies to improve the delivery efficiency to skeletal and cardiac muscles
  
  

Other Areas of Interest

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