Platform technology (new modalities and drug delivery systems)
Chemistry-driven novel methods or ideas to bring breakthrough into CNS drug discovery
We recruit a small molecule-based approach to a CNS therapeutic target. The followings are examples.
Chemistry-driven novel technologies, methods or ideas to solve issues on drug discovery with new modalities
We recruit research themes to solve issues in drug discovery using new modalities. The followings are examples.
Chemistry-driven novel technologies, methods or ideas to improve and/or accelerate drug discovery process
We recruit research themes to improve and/or accelerate the drug discovery process. The followings are examples.
Capsids with defined tissue tropisms (e.g. skeletal muscle) or capsids with reduced immunogenicity
Current viral capsids that are utilized in gene therapies (e.g. adeno associated virus [AAV]) tend to have a non-specific tissue tropism and induce a significant immune response post administration. In order to refine the delivery of next generation gene therapies the identification of capsids that preferentially target specific tissues and/or do not induce an immune response would potentially allow lower doses of vectors and/or allow dosing of patients with pre-existing immunity or allow re-dosing of previously treated patients.
Development of novel delivery technology for gene therapies
Recently, several AAVs are used as intravenous injection-enabled DDS for gene therapies, however, those have the issue of administration frequency due to the immunogenicity of AAV itself.
Here, we are seeking proposals for development of novel delivery materials or devices for gene therapies containing mRNA, siRNA or sgRNA meeting following conditions,
1) Non-viral based
2) Systemically available
3) Repeatedly available
4) Possess tissue tropism, particular skeletal muscles and heart
Furthermore, we are seeking novel technologies that can enhance delivery efficiency of existing DDS materials (e.g., novel CPP, hydrodynamic injection or bubble liposome and so on).
Follow the procedure below to make an application.
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Terms and Conditions for an application to COCKPI-T® Funding
We are sorry for the web system trouble that had happened from June 16th to July 29th. The web system has now been restored, but your application during the period was NOT received by us unfortunately. We appreciate it if you could resubmit it. Please send your application to the COCKPI-T Funding Office (COCKPI-T@takeda.com).
Please contact the COCKPI-T® Funding Office for further information.
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