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Platform technology (new modalities and drug delivery systems)

#25

Chemistry-driven novel methods or ideas to bring breakthrough into CNS drug discovery


We recruit a small molecule-based approach to a CNS therapeutic target. The followings are examples:

  • Drug discovery research based on innovative mechanism of action
    (e.g.) Ligands acting on DNA/RNAs (incl. splicing modulators), Small molecule chemical chaperones
  • Drug discovery research on tough targets
    (e.g.) Biased- or heterodimer-selective GPCR ligands, Allosteric ligands, Phosphatase inhibitors, Protein-protein interaction modulators


Note: Protein degradation inducer is recruited by subject #28.



#26

Chemistry-driven novel technologies, methods or ideas to solve issues on drug discovery with new modalities


We recruit research themes to solve issues in drug discovery using new modalities. The followings are examples:

  • Investigation of technologies for the improvement of efficacy, selectivity, and biodistribution of antisense oligonucleotides and siRNA
  • Research on Structure-Activity/Toxicity-Relationship in oligonucleotide drug discovery based on 3D structural analysis
  • Research on brain-targeted drug delivery technologies and evaluation of their mechanisms of action
  • Research on therapeutic modalities such as regenerative medicine and cell therapy using synthetic compounds



#27

Chemistry-driven novel technologies, methods or ideas to improve and/or accelerate drug discovery process


We recruit research themes to improve and/or accelerate the drug discovery process. The followings are examples:

  • Development of novel drug discovery algorithms based on artificial intelligence and/or molecular simulation
    (e.g.) Pharmacological activity and/or adverse effect prediction. Design of novel compounds
  • Drug discovery research based on polypharmacology
    (e.g.) Research on combination of therapeutic targets in terms of chemistry and pharmacology, Effective methodology for compound optimization
  • Technology of system which accelerate phenotypic drug discovery
    (e.g.) annotation/drug repositioning libraries, novel synthesis/building blocks of photoaffinity labeling probes
  • Development of in vitro/in vivo imaging probes for disease diagnosis, patient stratification



#28

Research on novel technologies and ideas in targeted protein degradation for drug discovery


We recruit research themes in targeted protein degradation area.

Areas of interest:

  • Computational chemistry technology to accelerate drug discovery process for targeted protein degrader
  • Drug discovery research on protein degradation inducer oriented to CNS therapeutic drug
  • Discovery of chimera molecule for ubiquitination independent target protein degradation
  • Research on teratogenicity of Cereblon (mechanism, evaluation method of teratogenicity, compound design in order to reduce the teratogenicity risk, etc.)



#29

Novel analysis methods and ideas associated with drug discovery based on human genetics


We recruit research themes that can accelerate drug discovery process by novel technology and idea based on human genetics.

Areas of interest:

  • Novel analytical methods based on human genetics not limited to additive genetic model
  • Prediction methods for the impact against genes or pathways by genomic variation (insertions, deletions, repeats, etc.)
  • Exploratory research on master transcription factors related to diseases pathogenesis
  • Structural biology research on epigenetics related to disease pathogenesis



#30

Novel analysis methods and ideas for exploring prediction-markers of disease-subpopulation based on human big data


We recruit research themes that can accelerate exploration of prediction-markers of disease-subpopulation based on human big data.

Areas of interest:

  • Time series data generated by digital device (sleep, perspiration, acceleration, brain imaging, EEG, etc.)
  • Omics data (Spatial transcriptome, Single cell, Exosome, etc.)



#31

Research on novel technologies and ideas of drug discovery targeting nucleic acids


We recruit research themes that can accelerate drug discovery process targeting nucleic acids.

Areas of interest:

  • Computational chemistry technology to accelerate RNA-targeting drug discovery
  • Research on synthetic compounds as innovative therapeutic modalities targeting nucleic acids
  • Technology to extract biologically significant RNA sequences that a small molecule can target



#32

Development of efficient drug delivery technologies to skeletal and cardiac muscles


Although various drug delivery technologies have been developed recently, it is still difficult to efficiently deliver drugs to skeletal and/or cardiac muscles. Therefore, we are seeking ideas for delivery technologies that can deliver DNA, RNA, protein and chemical compound to skeletal and/or cardiac muscles efficiently.

Specific examples:

  • Development of technologies to avoid or reduce the first-pass effect of liver
  • Development of viral vectors capable of escaping from the neutralizing antibodies
  • Development of delivery technologies by combining with other engineering technologies (ex, optical, magnetic, thermal or ultrasonic)
  • Development of liposomes or exosomes with skeletal and/or cardiac muscle tropisms
  • Regardless of above, technologies to improve the delivery efficiency to skeletal and cardiac muscles



Other Areas of Interest


How to Apply

Follow the procedure below to make an application.

  1. Download the Proposal Sheet below, and complete based on the non-confidential information.

  2. Click "SUBMIT". To proceed with the application you must agree with the Terms and Conditions that are presented to you. Once you have agreed with them, click “I ACCEPT”.

  3. Complete the Application Form with your Proposal Sheet prepared at Step1 attached, and click "SUBMIT".

  4. After submission, your website will show the “Submission Completed” page and you will receive a confirmation email.  


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CONTACT

Please contact the COCKPI-T® Funding Office for further information.

COCKPI-T@takeda.com

  

* Please be aware that we may not be able to respond to every inquiry.