Research on induction of antitumor effects of cells in the tumor microenvironment, particularly Treg, macrophage, fibroblast, and neutrophil, in cold tumors insensitive to immune checkpoint inhibitors
Focused research areas in this call:
Research areas out of focus in this call:
Development of CAR-engineered immune cells including T/NK cell products against novel solid and/or hematological malignancies targets
Chimeric antigen receptor engineered T cells (CAR-T cells) have made remarkable strides in the treatment of patients with B cell malignancies exemplified by anti-CD19 CAR-T cells in B cell acute lymphoblastic leukemia (B-ALL.). This success however has encountered hurdles in translation across hematological malignancies and even more so in solid tumors.
We welcome proposals aimed at the development of novel CAR-engineered immune cells including T/NK cell products against solid and/or hematological malignancies. Proposals aimed at overcoming limitations such as tumor selective expression, heterogeneous antigen expression, immunosuppressive networks in the tumor microenvironment, optimal CAR construct, T cell function and persistence, and inadequate trafficking are desired.
Research and development toward realization of innovative technology for next generation cellular cancer immuno-therapy
Remarkable modality change of recent cancer therapy, like immuno-checkpoint inhibitors and CAR-T cells, cancer immuno-therapy has been actively developed and that contrasts with traditional cancer therapies. In this subject, we are looking for innovative ideas and related technologies for cancer immuno-therapy applicable to cell therapy. Among them, the idea relating CAR-T cells is recruiting as another subject (#14), so we expect new proposals that are not related to CAR-T cells and will lead to differentiation from existing cancer therapies.
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