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Therapeutics-oriented Proposals

Neuroscience

REF#1

Innovative approaches to the below-listed diseases in neuroscience area, such as proposals addressing novel drug targets or identification of patient stratification/treatment-prediction biomarkers

 

  • Amyotrophic lateral sclerosis
  • Frontotemporal lobar degeneration
  • Alzheimer’s disease
  • Parkinson’s disease
  • Multiple system atrophy
  • Cerebral amyloid angiopathy
  • Huntington’s disease
  • Ataxias
  • Myotonic Dystrophy Type 1
  • Facioscapulohumeral muscular dystrophy
  • Charcot-Marie-Tooth disease
  • Myasthenia gravis
  • X-linked myotubular myopathy
  • Epilepsy
  • Note: For chemistry-driven approach, please submit your proposal as REF#2.

REF#2

Medicinal chemistry-based therapeutic approaches to address diseases in neuroscience area

Chemistry-driven drug discovery programs based on innovative mechanisms of action addressing the following aspects will be prioritized:

  • Protein degraders (AbTAC, AUTAC, PROTAC, etc.)
  • DNA/RNA-targeting molecules (e.g., RNA-binding proteins and/or their complex)
  • Polypharmacology-driven approaches

Diseases of high priority

  • Amyotrophic lateral sclerosis
  • Frontotemporal lobar degeneration
  • Alzheimer’s disease
  • Parkinson’s disease
  • Multiple system atrophy
  • Cerebral amyloid angiopathy
  • Huntington’s disease
  • Ataxias
  • Myotonic Dystrophy Type 1
  • Facioscapulohumeral muscular dystrophy
  • Charcot-Marie-Tooth disease
  • Myasthenia gravis
  • X-linked myotubular myopathy
  • Epilepsy
  • etc

REF#3

Highly innovative therapeutic approaches to CNS diseases based on human pathophysiology or physiology

Approaches of high novelty such as those addressing

  • Sleep/circadian rhythm
  • Waste clearance from the brain
  • Blood-brain barrier integrity
  • Neuroinflammation
  • Organelle homeostasis
  • DNA damage
  • Decline in sensory system
  • Resistance/protective factors against diseases (i.e. resilience)
  • Liquid‒liquid phase separation
  • Brain-gut interaction
  • Aberrancy in glial cells

The following diseases are out of focus:

    Multiple sclerosis, Acute ischemic stroke, Traumatic brain injury, Cerebral thrombosis, Cerebral hemorrhage, Spinal cord injury, Pain

Oncology

REF#4

Novel target molecules and concepts for immuno-oncology drug discovery

  • Novel targets and approaches to regulate innate immune cells for cancer immunotherapy
  • Innovative concepts to convert “cold” tumors, which is refractory to existing immunotherapy, into “hot” tumors
  • Cutting-edge research on tumor-intrinsic target molecules or biology (e.g., driver mutations, genomic instability, immune evasion mechanisms)
  • Novel therapeutic approach or target focusing on (1) cancer-associated fibroblasts, (2) tumor-infiltrating B cells or tertiary lymphoid structure (TLS), (3) tumor-draining lymph node
  • Exploration of novel cancer biology and resistance mechanisms based on multi-omics analysis of clinical samples utilizing single-cell or spatial analysis


Other Areas of Interest


How to Apply

Follow the procedure below to make an application.

  1. Download the Proposal Sheet below, and complete the application based on the non-confidential information.
  2. Click "Submit to COCKPI-T® Funding". To proceed with the submission you must agree with the Terms and Conditions that are presented to you. Once you have agreed with them, click “I ACCEPT”.
  3. Complete the Application Form with your Proposal Sheet prepared at Step1 attached, then click "SUBMIT".
  4. After submission, your website will show the “Submission Completed” page and you will receive a confirmation email.

Download the Proposal Sheet

For Therapeutics-oriented proposals

* File Format: docx, doc, pdf File size: up to 5MB

 

Core Terms and Conditions


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CONTACT

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