Reducing or eliminating the use or generation of hazardous substances in the design of our products and manufacturing processes is a key way to minimize the environmental, health and safety impacts of our products.
Takeda used “green chemistry” principles to create a process for the manufacturing of TAK-954, an investigational serotonin (5-HT4) receptor agonist. The project is an industry first that has been recognized with the American Chemical Society’s Peter J. Dunn Award for Green Chemistry and Engineering Impact in the Pharmaceutical Industry. The so-called “second-generation” process uses water as a reaction and isolation medium. Compared to the first-generation organic solvent-based process, it results in 78% less waste, eliminating two synthetic steps and 93% less organic solvent used. Perhaps surprisingly, it also uses 46% less water. Despite this, overall yield has increased from 35% to 56%.
Takeda is the first company in the pharmaceutical industry to use primary packaging made from bio-polyethylene (bio-PE), which helps reduce CO2 emissions by up to 70% compared to fossil-fuel derived polyethylene.
This innovation won us the Technical Packaging Award in the 2021 Japan Packaging Contest. We have also now been awarded the 2021 AsiaStar and the 2022 WorldStar Packaging Awards for the same innovation.
Takeda follows a life cycle approach committed to understanding, managing, and controlling the potential impact of pharmaceuticals in the environment. Takeda's PiE approach covers 3 activities: Environmental Risk Assessments, drug take-back, and emissions/effluent management.
Takeda partners with the European Federation of Pharmaceutical Industries and Associations (EFPIA) to improve methods to identify and quantify environmental risks of pharmaceutical products.