History    1985-1999

Takeda Medicines are Now Used Worldwide

1985

TAP Pharmaceuticals Inc. established, begins sales of Lupron^®

In 1985, Takeda formed TAP Pharmaceuticals Inc. in the U.S. in a 50:50 joint venture with Abbott Laboratories. TAP began marketing the prostate cancer treatment Lupron^® in the same year.

1988

Tsukuba Research Laboratories established

Tsukuba Research Laboratories became Takeda's second research base, coupled with the one in Osaka. These laboratories conduct basic research using cutting-edge technologies.

1989

Lupron Depot® launched

Effective for one full month with a single dosing, this was the successor to Lupron^®. It is now sold in around 80 countries worldwide, and is considered a gold standard therapy for prostate cancer. Also on the market now are 4 Month Depot (one dosing every 4 months) in the U.S.

1991

Lansoprazole (proton pump inhibitor and anti-peptic ulcer agent) launched in Europe

Lansoprazole is now sold in around 90 countries.

The success of Lupron Depot^® and Prevacid^® helped Takeda solidify its position as a global pharmaceutical manufacturer. These two drugs each now have worldwide sales exceeding $1 billion and have given us a firm business foundation in the U.S. and Europe.
In recent years, we further solidified our overseas bases to prepare for our new blockbuster drugs and aimed at greater business expansion.

1997

Candesartan Cilexetil (angiotensin II receptor antagonist and anti-hypertensive agent) launched in Europe

Candesartan is rebolutionizing hypertension treatment. In around 60 countries worldwide, it enjoys a trusted reputation in the medical profession.

Improvement of the business infrastructure in overseas

1997

, a wholly owned pharmaceutical marketing subsidiary, established in the U.K.

, a pharmaceutical manufacturing plant, established

Takeda Ireland Ltd has been working to meet the sharp increase in demand in the United States and Europe.

Takeda America Research & Development Center Inc. established

Takeda America Holdings, Inc., a holding company for our U.S. pharmaceutical business, established

1998

Majority share acquired in , a pharmaceutical marketing company in Italy

, a pharmaceutical marketing joint venture in France, becomes a wholly owned subsidiary of Takeda

Takeda Pharmaceuticals America, Inc. (now ), a wholly owned pharmaceutical marketing company, established in the U.S.

Takeda Pharmaceuticals America, Inc. began marketing the insulin sensitizer Actos^® in the next year.

, a pharmaceutical marketing company, established in Switzerland

Takeda Europe Research & Development Centre Ltd., (now Takeda Global Research & Development Centre (Europe), Ltd.) a pharmaceutical development company, established in the U.K.

1999

Actos^® (Pioglitazone Hydrochloride) launched in the U.S. and Japan

Actos^® improves insulin resistance and reduce blood sugar levels. It is marketed in around 80 countries worldwide. It has become Takeda's top-selling product.