Subsidiaries & Affiliates

North America
Europe
Asia
Japan

North America

Company Name	Address TEL FAX	Business	Takeda's Voting Shares Owned
Takeda America Holdings, Inc.	767 Third Avenue, 8th Floor New York, NY 10017, U.S.A TEL : + 1- 212- 421- 6954 FAX : + 1- 212- 355- 5243	Holding company	100%
	435 Tasso Street, Suite 300 Palo Alto, CA 94301, U.S.A TEL : + 1- 650- 328- 2900 FAX : + 1- 650- 328- 2922	Investment company	100% [*]
	10410 Science Center Drive, San Diego, CA 92121, U.S.A TEL : + 1- 858- 622- 8528 FAX : + 1- 858- 550- 0526	Research of pharmaceuticals	100% [*]
	285 East Grand Ave. South San Francisco, CA 94080-4804, U.S.A TEL : +1- 650-745-9332 FAX : +1- 650-589-5425	Research of pharmaceuticals	100% [*]
	One Takeda Parkway, Deerfield, IL 60015, U.S.A TEL : + 1- 224 - 554 - 6500	Development of pharmaceuticals	100% [**]
Takeda Pharmaceuticals International, Inc.	One Takeda Parkway, Deerfield, IL 60015, U.S.A TEL : + 1- 224 - 554 - 6500	Operations Research & Development of pharmaceuticals and Overseas Sales & Marketing	100% [*]
	One Takeda Parkway, Deerfield, IL 60015, U.S.A TEL : + 1- 224 - 554 - 6500	Sale of pharmaceuticals	100% [*]
	40 Landsdowne Street, Cambridge, MA 02139, U.S.A TEL : +1- 617-679-7000 FAX : +1- 617-374-7788	Research, Development and sale of pharmaceuticals	100% [*]
	6750 Century Avenue Suite 400 Mississauga, Ontario, Canada L5N 2V8 TEL:+1-905-814-2300 FAX:+1-905-814-2498	Sale of pharmaceuticals	100% [*]

Note: Companies marked with [*] are subsidiaries or affiliates of Takeda America Holdings, Inc.
Note: Companie marked with [**] is a 100% subsidiary of Takeda Pharmaceuticals North America, Inc.

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Europe

Company Name	Address TEL FAX	Business	Takeda's Voting Shares Owned
Takeda Europe Holdings B.V.	WTC Amsterdam A-12, Strawinskylaan 1217, 1077 XX Amsterdam, Holland	Holding company	100%
	418 Cambridge Science Park Cambridge, CB4 0PA, UK TEL: +44-1223-477-910 Fax: +44-1223-477-911	Research of pharmaceuticals	100% [***]
Takeda Global Research & Development Centre (Europe) Ltd.	61 Aldwych, London, WC2B 4AE, UK TEL: +44-20-3116-8000 FAX: +44-20-3116-8001	Development of pharmaceuticals	100% [***]
Takeda Pharmaceuticals Europe Limited	61 Aldwych, London, WC2B 4AE, UK TEL: +44-20-3116-8000 FAX: +44-20-3116-8001	Operations European Sales & Marketing	100% [***]
	15 Quai de Dion Bouton, 92816 Puteaux Cedex, France TEL : + 33- 1- 4625- 1616 FAX : + 33- 1- 4697- 0011	Sale of pharmaceuticals	100% [***]
	Takeda House, Mercury Park, Wycombe Lane, Wooburn Green, High Wycombe, Buckinghamshire, HP10 0HH, UK TEL : + 44- 1628- 537- 900 FAX : + 44- 1628- 526- 615	Sale of pharmaceuticals	100% [***]
	Via Elio Vittorini,129, 00144 Rome, Italy TEL : + 39- 06- 502601 FAX : + 39- 06- 5011709	Sale of pharmaceuticals	76.9% [***]
	Viktoriaallee 3- 5,52066 Aachen, Germany TEL : + 49- 241- 941- 0 FAX : + 49- 241- 941- 1120	Sale of pharmaceuticals	100% [***]
	Seidengasse 33- 35, A- 1070,Vienna, Austria TEL : + 43- 1- 524- 40- 64 FAX : + 43- 1- 524- 40- 66	Sale of pharmaceuticals	100% [****]
	Alpenblickstrasse 26 CH- 8853 Lachen, Switzerland TEL : + 41- 55- 451- 5200 FAX : + 41- 55- 451- 5220	Sale of pharmaceuticals	100% [****]
Takeda Farmacéutica España S.A.	Regus Business Centre Avenida Diagonal 640, Planta 6 08017 Barcelona, Spain TEL : + 34- 93- 228- 7824 FAX : + 34- 93- 228- 7869	Sale of pharmaceuticals	100% [***]
Takeda Farmacêuticos Portugal, Unipessoal LDA	Avª. da Torre de Belém, Nº 19 - 1º E 1400-342 Lisboa, Portugal TEL : + 351- 21- 120- 1457 FAX : + 351- 21- 120- 1456	Sale of pharmaceuticals	100% [***]
	Bray Business Park, Kilruddery, Co. Wicklow, Ireland TEL : + 353- 1- 205- 0600 FAX : + 353- 1- 205- 0601	Manufacture of pharmaceuticals	100%

Note: Companies marked with [***] are subsidiaries or affiliates of Takeda Europe Holdings, B.V.
Note: Companies marked with [****] are 100% subsidiary of Takeda Pharma GmbH.

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Asia

Company Name	Address TEL FAX	Business	Takeda's Voting Shares Owned
	10 Biopolis Road, #03-01/02 Chromos, Singapore 138670 TEL : +65-677-11300 Fax : +65-647-89576	Research and development of pharmaceuticals	100% [*****]
Takeda Clinical Research Singapore Private Limited	2 Shenton Way, #11-01 SGX Centre 1, Singapore 068804 TEL : +65 6521 2100 Fax : +65 6521 2272	Clinical Operations in Asian-Oceania region	100.0%
Takeda Pharmaceuticals Asia Private Limited	2 Shenton Way, #11-01 SGX Centre 1, Singapore 068804 TEL : +65 6521 2100 Fax : +65 6521 2271	Operations Asian Sales & Marketing	100.0%
Tianjin Takeda Pharmaceuticals Co., Ltd.	No. 11, Xinghua Road, Tianjin Xiqing, Economic Development Area,Tianjin, China TEL : + 86- 22- 2397- 0011 FAX : + 86- 22- 2397- 2230	Manufacture and sale of pharmaceuticals	75%
Takeda Pharmaceuticals Taiwan, Ltd.	7th Floor, Great China Bldg., No. 217, Sec. 3, Nanking East Road,Taipei, Taiwan TEL : + 886- 2- 2712- 1112 FAX : + 886- 2- 2712- 1118	Sale of pharmaceuticals	100%
Takeda Pharmaceuticals (Philippines), Inc.	12th Floor, Sky Plaza Bldg., 6788 Ayala Avenue, Oledan Square, Makati City, Metro Manila, Philippines TEL : + 63- 2- 886- 6954 or 6961 FAX : + 63- 2- 886- 6941	Sale of pharmaceuticals	50%
Takeda (Thailand), Ltd.	10th Floor, Rajanakarn Bldg.183 South Sathorn Road, Kwang Yannawa, Khet Sathorn, Bangkok 10120, Thailand TEL : + 66- 2- 676- 6770 FAX : + 66- 2- 676- 6780	Sale of pharmaceuticals	48%
P.T. Takeda Indonesia	Plaza DM 15th Floor, JI. Jend. Sudirman Kav. 25, Jakarta 12920, Indonesia TEL : + 62- 21- 526- 7656 FAX : + 62- 21- 526- 7657	Manufacture and sale of pharmaceuticals	70%

Note: Company marked with [*****] is a 100% subsidiary of Takeda Cambridge Limited.

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Japan

Company Name	Address TEL FAX	Business	Takeda's Voting Shares Owned
	9-8, Higashikanda 1-chome Chiyoda-ku, Tokyo 101-0031, Japan TEL: +81-3-3864-8411 FAX: +81-3-3864-8837	Manufacture, sale, research and development of pharmaceuticals	87.5%
Takeda Healthcare Products Co., Ltd.	21, Osadano-cho 2-chome Fukuchiyama-shi, Kyoto 620-0853, Japan TEL: +81-773-27-5421 FAX: +81-773-27-5489	Manufacture of pharmaceuticals	100%
Takeda Bio Development Center Limited	7-12, Marunouchi 1-chome Chiyoda-ku, Tokyo 100-0005, Japan TEL: +81-3-5224-9050	Development of pharmaceuticals	100%
	995 Saso-cho Fukuchiyama-shi, Kyoto 620-0932, Japan TEL: +81-773-22-1100 FAX: +81-773-23-3355	Research, development, manufacture and marketing of pharmaceuticals	30%
	1-2, Doshomachi 3-chome Chuo-ku, Osaka 541-0045, Japan TEL: +81-6-6203-3741 FAX: +81-6-6203-2029	Manufacture and sale of laboratory chemicals, specialty chemicals and diagnostic reagents	70.3%

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